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Molecular Cardiology Research Institute
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 Did you know . . .

 

- The MCRI is a world leader in molecular cardiology and cardiovascular research.

 

- MCRI investigators conduct molecular, cellular and translational research on blood vessels and vascular cells.

 

- MCRI investigators conduct molecular, cellular and translational research on the heart and cardiac cells.

 

- MCRI funding comes from the National Institutes of Health, many foundations, and private donations.



MCRI in the News

 

August 20, 2008 - In the Journal of the American College of Cardiology published today, Tufts Medical Center researchers, led by the MCRI's Dr. Richard Karas, report that the cholesterol-lowering drugs called statins neither cause cancer nor prevent it. 

 

May 1, 2008 - In a study published in the Proceedings of the National Academy of Sciences, MCRI researchers identify a new mechanism for high blood pressure.  The team, led by Dr. Michael Mendelsohn, found that blood vessel abnormalities, not just kidney abnormalities as has previously been believed, can cause high blood pressure.

 

February 1, 2008 - Richard Karas, MD, PhD is appointed as Vice Chairman of Scientific Affairs for the Department of Medicine

 

 

February 1, 2008 - Tufts Medical Center announced today that Michael E. Mendelsohn, MD will lead the organization’s research endeavors as Chief Scientific Officer

 

January 1, 2008 - MCRI Celebrates 10 Years of Ground-breaking Cardiovascular Research

 

MCRI Training and Staff Opportunities are available.

Selected MCRI Publications

 

Davis BN, Hilyard AC, Lagna G, Hata A.  SMAD proteins control DROSHA-mediated microRNA maturation.  Nature 2008; 454(7200):56-61.  PubMed Abstract

 

Mendelsohn ME, Karas RH.  HRT and the Young at Heart.  New England Journal of Medicine 2007; 356(25):2639-2641.  PubMed Abstract

 

Mendelsohn ME.  Viagra: Now mending hearts.  Nature Medicine 2005; 11(2):115-116.  PubMed Abstract

 

Mendelsohn ME, Karas RH.  Molecular and cellular basis of cardiovascular gender differences.  Science 2005; 308(5728):1583-1587.  PubMed Abstract

 

Blaustein RO, Miller C.  Ion channels: Shake, rattle or roll?  Nature 2004; 427:499-500.  PubMed Abstract

 

Tang M, Wang G, Lu P, Karas RH, Aronovitz M, Heximer SP, Kaltenbronn KM, Blumer KJ, Siderovski DP, Zhu Y, Mendelsohn ME.  Regulator of G-protein signaling 2 mediator vascular smooth muscle relaxation and blood pressure.  Nature Medicine 2003; 9(12):1506-1512.  PubMed Abstract

 

Covic L, Jacques SL, Kuliopulos A.  Inhibition of platelet thromboxane receptor function by a thrombin receptor-targeted pepducin.  Nature Medicine 2003; 9(12):1447-1448.

 

Hattar S, Lucas RJ, Mrosovsky N, Thompson S, Douglas RH, Hankins MW, Lem J, Biel M, Hofmann F, Foster RG, Yau K-W.  Melanopsin and rod-cone photoreceptive systems account for all major accessory visual functions in mice.  Nature 2003; 424:76-81.  PubMed Abstract

 

Haq S, Kilter H, Michael A, Tao J, O'Leary E, Sun XM, Walters B, Bhattacharya K, Chen X, Cui L, Andreucci M, Rosenzweig A, Guerrero JL, Patten R, Liao R, Molkentin J, Picard M, Bonventre JV, Force T.  Deletion of Cytosolic phospholipase A(2) promotes striated muscle growth.  Nature Medicine 2003; 9(7):944-951.  PubMed Abstract

 

Mendelsohn ME, Karas RH.  Mechanisms of Disease: The protective effects of estrogen on the cardiovascular system.  New England Journal of Medicine 1999; 340(23):1801-1811.  PubMed Abstract

 

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