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Molecular Cardiology Research Institute
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 Did you know . . .

 

The MCRI is a world leader in molecular cardiology and cardiovascular research.

 

- MCRI investigators conduct molecular, cellular and translational research on blood vessels and vascular cells.

 

- MCRI investigators conduct molecular, cellular and translational research on the heart and cardiac cells.

 

- MCRI funding comes from the National Institutes of Health, many foundations, and private donations.



MCRI News

 

August 20, 2008 - In the Journal of the American College of Cardiology published today, Tufts Medical Center researchers, led by the MCRI's Dr. Richard Karas, report that the cholesterol-lowering drugs called statins neither cause cancer nor prevent it. 

 

May 1, 2008 - In a study published in the Proceedings of the National Academy of Sciences, MCRI researchers identify a new mechanism for high blood pressure.  The team, led by Dr. Michael Mendelsohn, found that blood vessel abnormalities, not just kidney abnormalities as has previously been believed, can cause high blood pressure.

 

February 1, 2008 - Richard Karas, MD, PhD is appointed as Vice Chairman of Scientific Affairs for the Department of Medicine

 

 

February 1, 2008 - Tufts Medical Center announced today that Michael E. Mendelsohn, MD will lead the organization’s research endeavors as Chief Scientific Officer

 

January 1, 2008 - MCRI Celebrates 10 Years of Ground-breaking Cardiovascular Research

 

MCRI Training and Staff Opportunities are available.

Selected MCRI Publications

 
Vitale C, Mendelsohn ME, Rosano GM.  Gender differences in the cardiovascular effect of sex hormones.  Nature Reviews Cardiology 2009; 6(8):532-542.  PubMed Abstract

 

Park HJ, Zhang Y, Du C, Welzig CM, Madias C, Aronovitz MJ, Georgescu SP, Naggar I, Wang B, Kim YB, Blaustein RO, Karas RH, Liao R, Mathews CE, Galper JB.  Role of SREBP-1 in the Development of Parasympathetic Dysfunction in the Hearts of Type 1 Diabetic Akita Mice.  Circulation Research 2009; 105(3):278-294.  PubMed Abstract


Fortin JP, Zhu Y, Choi C, Beinborn M, Nitabach MN, Kopin AS.  Membrane-tethered ligands are effective probes for exploring class B1 G protein-coupled receptor function.  Proceedings of the National Academy of Sciences, USA 2009; 106(19):8049-8054   PubMed Abstract


Schultz K, Murthy V, Tatro JB, Beasley D.  Prolyl hydroxylase 2 deficiency limits proliferation of vascular smooth muscle cells by HIF-1{alpha}-dependent mechanisms.  American Journal of Physiology - Lung Cellular and Molecular Physiology 2009; 296(6):L921-L927.   PubMed Abstract


Neuman NA, Ma S, Schnitzler GR, Zhu Y, Lagna G, Hata A.  The four-and-a-half lim domain protein 2 regulates vascular smooth muscle phenotype and vascular tone.  Journal of Biological Chemistry 2009; 284(19):13202-13212.   PubMed Abstract

 

Zhong J, Gavrilescu LC, Molnár A, Murray L, Garafalo S, Kehrl JH, Simon AR, Van Etten RA, Kyriakis JM.  GCK is essential to systemic inflammation and pattern recognition receptor signaling to JNK and p38.  Proceedings of the National Academy of Sciences, USA 2009;106(11):4372-4377.  PubMed Abstract

 

Sweet TB, Cox DH.  Measuring the influence of the BKca β1 subunit on Ca²+ binding to the BKca channel.  Journal of General Physiology 2009;133(2):139-150.  PubMed Abstract

 

Takimoto E, Koitabashi N, Hsu S, Ketner EA, Zhang M, Nagayama T, Bedja D, Gabrielson KL, Blanton R, Siderovski DP, Mendelsohn ME, Kass DA.  Regulator of G protein signaling 2 mediates cardiac compensation to pressure overload and antihypertrophic effects of PDE5 inhibition in mice.  Journal of Clinical Investigation 2009;119(2):408-420.  PubMed Abstract

 

Davis BN, Hilyard AC, Lagna G, Hata A.  SMAD proteins control DROSHA-mediated microRNA maturation.  Nature 2008; 454(7200):56-61.  PubMed Abstract

 

Kerkela R, Kockeritz L, Macaulay K, Zhou J, Doble BW, Beahm C, Greytak S, Woulfe K, Trivedi CM, Woodgett JR, Epstein JA, Force T, Huggins GS.  Deletion of GSK-3β in Mice Leads to Hypertrophic Cardiomyopathy Secondary to Cardiomyoblast Hyperproliferation.  Journal of Clinical Investigation 2008;118(11):3609-3618.  PubMed Abstract

 

Caprio M, Newfell BG, la Sala A, Baur W, Fabbri A, Rosano G, Mendelsohn ME, Jaffe IZ.  Functional mineralocorticoid receptors in human vascular endothelial cells regulate intercellular adhesion molecule-1 expression and promote leukocyte adhesion.  Circulation Research 2008;102(11):1359-1367.  PubMed Abstract

 

Michael S, Surks HK, Wang Y, Zhu Y, Blanton R, Jamnongit M, Aronovitz M, Baur W, Ohtani K, Wilkerson MK, Bonev AD, Nelson MT, Karas RH, Mendelsohn ME.  High blood pressure arising from a defect in vascular function.  Proceedings of the National Academy of Sciences, USA 2008;105(18):6702-6707.  PubMed Abstract

 

Park HJ, Georgescu SP, Du C, Madias C, Aronovitz MJ, Welzig CM, Wang B, Begley U, Zhang Y, Blaustein RO, Patten RD, Karas RH, Van Tol HH, Osborne TF, Shimano H, Liao R, Link MS, Galper JB.  Parasympathetic response in chick myocytes and mouse heart is controlled by SREBP.  Journal of Clinical Investigation 2008;118(1):259-271.  PubMed Abstract

 

Brill E, Malanson KM, Radu RA, Boukharov, NV, Wang Z, Chung H-Y, Lloyd MB, Bok D, Travis GH, Obin M, Lem J.  A novel form of transducin-dependent retinal degeneration: Accelerated retinal degeneration in the absence of rod transducin.  Investigative Ophthalmology & Visual Science 2007;48(12):5445-5453.  PubMed Abstract

 

Mendelsohn ME, Karas RH.  HRT and the Young at Heart.  New England Journal of Medicine 2007; 356(25):2639-2641.  PubMed Abstract

 

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